Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor
نویسندگان
چکیده
منابع مشابه
Identification of the functional interleukin-2 binding domain of the chicken common cytokine receptor gamma chain.
CD132 is the common gamma chain to a number of cytokine receptor complexes including that for IL-2. To identify the functional domain of chicken CD132 (chCD132), the cDNA of chCD132 was cloned, and a neutralizing monoclonal antibody, raised against a recombinant chCD132 protein, was identified by inhibition of IL-2-dependent proliferation of T cells. Flow cytometry analysis revealed that chCD13...
متن کاملThe interleukin-2 receptor.
The human body defends itself against foreign invaders such as bacteria and viruses by a defense system that involves antibodies and thymus-derived lymphocytes (T cells). A major advance over the past decade has been the demonstration that the diverse cells within the immunological network communicate with each other not only by cell/cell contact but also by an array of hormone-like proteins te...
متن کاملSevere combined imunodeficiency caused by defect of the common gamma chain of the interleukin 2 receptor
Results The mutation detected was a defect of the common gamma chain of the interleukin 2 receptor (IL2Rg). Even though genetic counseling advised otherwise the patient’s mother got pregnant during follow-up and as no compatible donor was found we chose to wait birth and verify compatibility. Genetic evaluation of the newborn revealed the absence of the IL2Rg gene defect in blood cord and a mat...
متن کاملIL 7 R ( interleukin 7 receptor )
Review on IL7R, with data on DNA/RNA, on the protein encoded and where the gene is implicated.
متن کاملExpression of the interleukin-2 receptor gamma chain on cord blood mononuclear cells.
Lymphocytes in umbilical cord blood and neonatal peripheral blood have been shown to have less ability in an immune reaction. In our present experimental approach to address this issue, we made use of the cord blood of full-term birth infants to investigate the expression of the interleukin- 2 receptor gamma (IL-2Rgamma) chain that is shared with receptors for IL-4, IL-7, IL-9, and IL-15 as wel...
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ژورنال
عنوان ژورنال: Science
سال: 1993
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.8266077